Bound water molecules and conformational stabilization help mediate an antigen-antibody association.
نویسندگان
چکیده
منابع مشابه
Antibody molecules and the antigen-antibody interaction
The immune system is a diffuse organ dispersed in the body and basically constitutes lymphoid cells, cytokine and antibody molecules. The latter are the product of lymphoid cells. In the past, the cellular basis for antibody formation was the subject of several theories, e.g., the selective theory according to P EHRLICH (1900), the instructive antigen-template theories as suggested by L PAULING...
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The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.3.1089